lnterleukin-1 activates transcription factor NFKB in glial cells
نویسندگان
چکیده
Recombinant human interleukin-1 (IL-I) ac and , were found to activate a latent cytosolic form of the transcription factor NFKB in rat C6 glioma. IL-if? was 10 times more potent than IL-1 a for this activity and both were inhibited by the IL-1 receptor antagonist. The activation was detectable from 20 min and remained sustained for up to 24 h. The electrophoretic mobility of the activated complex was shown to be different from that of the corresponding complexes in another IL-I-responsive cell line,
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